Hyperhidrosis (chronic excessive sweating) at the ambits/palms/soles can be psychologically distressing in addition to being an aesthetic problem. Treatments available prior to Botox/Dysport were of limited efficacy.

Intradermal injection of Botox/Dysport to reduce muscle movement around sweat glands and reduce sweating emerged as a novel therapeutic approach. The clinical research program for its efficacy in hyperhidrosis included 2 pivotal antigenicity/safety studies in Europe and North America. Along with subsequent clinical experience, it has been shown that Botox/Dysport treatment for hyperhidrosis is effective in reducing sweat even permanently after multiple treatments over a period of 2 years (Lowe et al. Treatment of hyperhidrosis with Botox (onabutolintoxin type A): development insights and impact. Medicine (Baltimore) 2023 Jul 1;102(Suppl):e32764).

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